A targeted BioSqueeze is performed in a similar fashion to a standard cement retainer squeeze, with a short interval targeted for perforation, a bridge plug set below, a packer set above and tubing run to pump fluids into the leakage pathways. BioSqueeze is then squeezed at low rate and high pressure into the leakage pathways utilizing low viscosity fluids to penetrate deep and form crystalline calcium carbonate. After several stages pumped over the course of a couple days permeability is reduced completely resulting in in a comprehensive gas-tight seal for hundreds of feet from the point of injection.